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Dr. Mario + Puzzle League is a Game Boy Advance compilation featuring two timeless puzzle hits from Nintendo. Players can switch between Dr. Mario, the virus-busting classic, and Puzzle League, a fast-paced color-matching challenge originally known as Panel de Pon or Tetris Attack.
Released in 2005, this collection brings together two highly addictive games on one cartridge. Dr. Mario challenges players to eliminate viruses using color-matching capsules, while Puzzle League tasks you with aligning falling blocks to clear them and score combos. Each game includes multiple difficulty settings, modes, and two-player functionality via link cable.
You can play Dr. Mario + Puzzle League for free online in your browser. No emulator or download is needed—just load and play instantly. Compete against the clock, aim for high scores, or test your puzzle skills anywhere.
Dr. Mario + Puzzle League delivers double the puzzle action on the Game Boy Advance. Whether you prefer strategic virus-clearing or rapid tile-matching, this compilation is perfect for quick sessions or marathon play. Test your reflexes and puzzle-solving skills with two of Nintendo’s best puzzle games—now playable online!